In this paper we propose a multivariate extension of family‐based association tests based
on generalized estimating equations. The test can be applied to multiple phenotypes and to …

Sarcoidosis, in the United States, more commonly and severely affects African Americans.
HLA associations with sarcoidosis have been reported, but most studies used case-control …

BACKGROUND: Behavioral inhibition to the unfamiliar (BI), a heritable temperamental
profile involving an avoidant response to novel situations, may be an intermediate …

A recent study identified the ADAM33 gene as a promising candidate contributing to asthma.
In Puerto Rican and Mexican populations, we have genotyped six single nucleotide …

BACKGROUND: β2-Adrenergic receptor (B2AR) polymorphisms have been associated with
a variety of asthma-related phenotypes, but association results have been inconsistent …

We introduce a new powerful nonparametric testing strategy for family-based association
studies in which multiple quantitative traits are recorded and the phenotype with the …

Abstract Selective IgA deficiency (IgAD) and common variable immunodeficiency (CVID) are
the most common primary immunodeficiencies in humans. A high degree of familial …

Investigators have intensively evaluated the major histocompatibility (MHC) complex for
sarcoidosis susceptibility genes with the majority of reports implicating the human leukocyte …

For genetic association studies with multiple phenotypes, we propose a new strategy for
multiple testing with family-based association tests (FBATs). The strategy increases the …

Abstract Alpha-2-Macroglobulin (A2M) is a highly plausible candidate gene for Alzheimer's
disease (AD) in a region of chromosome 12 that has numerous independent reports of …