Studies of early-onset recurrent depression, late life depression associated with neurologic
disorders, and bipolar illness have revealed structural brain changes within a …

The past decade has seen a steady accumulation of evidence supporting a role for the
excitatory amino acid (EAA) neurotransmitter, glutamate, and its receptors in depression and …

Background Suicide is a major public health concern. Although authors of many studies
have examined the neurobiological aspects of suicide, the molecular mechanisms …

OBJECTIVE: Animal studies have suggested that early stress is associated with alterations
in the hippocampus, a brain area that plays a critical role in learning and memory. The …

Recent studies have indicated that exogenously administered neurotrophins produce
antidepressant-like behavioral effects. We have here investigated the role of endogenous …

Adult hippocampal neurogenesis has been demonstrated in several species and is
regulated by both environmental and pharmacological stimuli. The present study seeks to …

BACKGROUND: Previous work has shown that brain-derived neurotrophic factor (BDNF)
and its receptor, tyrosine kinase receptor B (TrkB), are involved in appetitive behavior. Here …

BACKGROUND: Animal studies have shown that stress is associated with damage to the
hippocampus, inhibition of neurogenesis, and deficits in hippocampal-based memory …

In a novel theory, a failure of adult hippocampal neurogenesis has been proposed to
provide the biological and cellular basis of major depression. The as yet unresolved function …

There is growing evidence from neuroimaging and ostmortem studies that severe mood
disorders, which have traditionally been conceptualized as neurochemical disorders, are …