Darier's disease and Hailey–Hailey disease are autosomal dominantly inherited skin
disorders in which desmosomal adhesion between keratinocytes is abnormal. ATP2A2 and …

Keratinocytes are the prevalent cell type of the epidermis, a multilayered cornified epithelium
which provides the cellular basis of the outermost barrier between the organism and its …

Human skin consists of a stratified, cellular epidermis and an underlying dermis of
connective tissue [1–5]. The dermal–epidermal junction is undulating in section; ridges of …

Snail, a transcriptional repressor of E-cadherin expression, is involved in epithelial-
mesenchymal transitions during development. We demonstrate that Snail activity is not …

Repair of wounded epidermis requires both keratinocyte migration and deposition of laminin
5 over exposed dermal collagen. To understand the coupling between leading cell migration …

Dermatological diseases range from minor cosmetic problems to life-threatening conditions,
as seen in some severe disorders of keratinization and cornification. These disorders are …

Although the regulation of hemidesmosome dynamics during processes such as epithelial
migration, wound healing, and carcinoma invasion is important, the mechanisms involved …

The Msx homeobox gene family consists of three physically unlinked members in the
mammalian genome (Holland, 1991; Monaghan et al., 1991; Shimeld et al., 1996). During …

Background Several hereditary human diseases are now known to be caused by distinct
mutations in genes encoding various desmosome components. Although the effects of some …

Reasons for performing study: The key lesion of laminitis is separation at the hoof lamellar
dermal‐epidermal interface. For this to happen the structural and adhesion proteins of the …