Stress promotes adaptation, but prolonged stress leads over time to wear‐and‐tear on the
body (allostatic load). Neural changes mirror the pattern seen in other body systems, that is …

Life history theory provides a metatheoretical framework for the study of pubertal timing from
an evolutionary-developmental perspective. The current article reviews 5 middle-level …

The limited success of genetic studies of major depression has raised questions concerning
the definition of genetically relevant phenotypes. This paper presents strategies to improve …

Background Functional imaging studies of major depressive disorder demonstrate response-
specific regional changes following various modes of antidepressant treatment. Objective To …

Objective: The present paper reviews the evidence that depression is a risk factor for the
development and progression of coronary artery disease (CAD). Methods: MEDLINE …

Background: The key role of prevention and treatment of mental disorders in the prevention
of suicide is widely acknowledged. Which specific disorders need to be targeted remains to …

Reduced serotonin transporter (5-HTT) expression is associated with abnormal affective and
anxiety-like symptoms in humans and rodents, but the mechanism of this effect is unknown …

This paper reports the results of an across lab metanalysis of effective connectivity in major
depression (MDD). Using FDG PET data and Structural Equation Modeling, a formal …

There is now a large body of evidence that supports the conclusion that individual
differences in most, if not all, reliably measured psychological traits, normal and abnormal …

Anxiety is a mental state that is elicited in anticipation of threat or potential threat. Sensations
of anxiety are a normal part of human experience, but excessive or inappropriate anxiety …