The nature of microglia fascinated many prominent researchers in the 19th and early 20th
centuries, and in a classic treatise in 1932, Pio del Rio-Hortega formulated a number of …

Human African trypanosomiasis (HAT), also known as sleeping sickness, is a major cause of
mortality and morbidity in sub-Saharan Africa. Current therapy with melarsoprol for CNS …

Innate and adaptive immunity function to eliminate foreign invaders and respond to injury
while enabling coexistence with commensal microbes and tolerance against self and …

Subspecies of Trypanosoma brucei cause severe brain diseases after penetration of the
blood-brain barrier. We investigated whether cytokines that modulate inflammatory cell …

Trypanosomes cause African sleeping sickness, affecting millions of humans and animals.
We tested trypanosome microtubule-associate protein (MAP p15) as a vaccine in mice, and …

MHC class I tetramers are widely used, usually in combination with an antibody to CD8, to
detect antigen specific T cells. Some anti-CD8α antibodies block the interaction of murine …

The interaction between the blood protozoan parasite, Trypanosoma brucei and the
gastrointestinal nematode parasite, Strongyloides ratti was studied in outbred white albino …

In vivo and ex vivo studies of the immune system in relation to infectious disease that are
carried out in the natural target species provide data that are relevant to understanding the …

In African trypanosomiasis the host-derived cytokine interferon-γ (IFN-γ) has been identified
as a potent growth promoter of the causative agent Trypanosoma brucei brucei (Tbb). The …