Display of heterologous proteins on the surface of micro‐organisms, enabled by means of
recombinant DNA technology, has become an increasingly popular strategy in microbiology …

We report the use of CotC, a major component of the Bacillus subtilis spore coat, as a fusion
partner for the expression of two heterologous antigens on the spore coat. Recombinant …

The mucosal and cellular responses of mice were studied, following mucosal-route
administration of recombinant Lactococcus lactis expressing tetanus toxin fragment C …

The potential of recombinant lactic acid bacteria (LAB) to deliver heterologous antigens to
the immune system and to induce protective immunity has been best demonstrated by using …

Recombinant Bacillus subtilis spores were employed as a vaccine delivery system in a
heterologous mucosal priming-parenteral boosting vaccination strategy in the mouse model …

Purpose. The purpose of this study was to use in vivo phage display screening technology to
identify novel lead peptides that target delivery to M cells and to follicle-associated …

The looming threat of bioterrorism has enhanced interest in the development of vaccines
against agents such as botulinum toxin. This in turn has stimulated efforts to create vaccines …

ABSTRACT A nontoxic mutant diphtheria toxin fragment A (DTA) was genetically fused in
single, double, or triple copy to the major surface protein antigen P1 (SpaP) and surface …

Gram-positive bacterium Streptococcus gordonii, a human oral commensal, was engineered
to display a single-chain Fv (scFv) antibody fragment at the cell surface. The previously …

El uso de vacunas desde principios del siglo pasado, y la introducción de los antibióticos y
de las prácticas de higiene modernas unas cuantas décadas después, han contribuido …