Today, we know that a primary metabolic action of insulin is to facilitate the postprandial
disposition of glucose via its actions on three key target tissues: suppression of glucose …

Glucagon-like peptide (GLP)-1 is an incretin hormone with potent glucose-dependent
insulinotropic and glucagonostatic actions, trophic effects on the pancreatic β-cells, and …

Insulin and glucagon are potent regulators of glucose metabolism. For decades, we have
viewed diabetes from a bi-hormonal perspective of glucose regulation. This perspective is …

OBJECTIVE—Liraglutide is a long-acting glucagon-like peptide 1 analog designed for once
daily injection. This study assessed the efficacy and safety of liraglutide after 12 weeks of …

This study assessed whether glucose-dependent insulin secretion and overall
counterregulatory response are preserved during hypoglycemia in the presence of …

Glucagon-like peptide-1 (GLP-1) is a peptide hormone from the gut that stimulates insulin
secretion and protects β-cells, inhibits glucagon secretion and gastric emptying, and …

Glucagon-like peptide-1 (7-36)-amide (GLP-1) is an endogenous 30-amino acid gut peptide,
which binds at the GLP-1 receptor coupled to the cyclic AMP second messenger pathway …

Glucagon‐like peptide‐1 (GLP‐1) is an intestinally derived insulinotropic hormone currently
under investigation for use as a novel therapeutic agent in the treatment of type 2 diabetes …

The glucagon-like peptides (glucagon-like peptide-1 (GLP-1) and glucagon-like peptide-2
(GLP-2)) are released from enteroendocrine cells in response to nutrient ingestion. GLP-1 …

Abstract Glucagon-like peptide 1 (GLP-1) was discovered as an incretin (insulinotropic gut)
hormone. Biological actions of GLP-1 in healthy and type 2 diabetic subjects include (a) …