Glutathione is an abundant natural tripeptide found within almost all cells. Glutathione is
highly reactive and is often found conjugated to other molecules via its sulfhydryl moiety. It …

Living beings have evolved over the past two billon years through adaptation, to an
increasing atmospheric oxygen concentration, by both taking advantage of oxygen …

The endothelial generation of reactive oxygen species (ROS) is important both
physiologically and in the pathogenesis of many cardiovascular disorders. ROS generated …

Epidemiological studies continue to support the premise that dietary intake of Allium
vegetables (eg, garlic, onions and so forth) may lower the risk of various types of cancer …

Production of pyocyanin enhances Pseudomonas aeruginosa virulence. Many of
pyocyanin's in vitro and in vivo cytotoxic effects on human cells appear to result from its …

Age-related depletion of GSH levels and perturbations in its redox state may be especially
deleterious to metabolically active tissues, such as the heart and brain. We examined the …

The gram-positive human pathogen Staphylococcus aureus is often isolated with media
containing potassium tellurite, to which it has a higher level of resistance than Escherichia …

When exposed to hypoxia (1.5% O2), several cell types have been shown to increase
production of reactive O2 species derived from the mitochondrial electron transport chain …

The stabilization of the reduction state of proteins and peptides is very important for the
monitoring of protein–protein, protein–DNA and protein–xenobiotic interactions. The …

Lead (Pb) and paraquat (PQ) have different toxic mechanisms associated with cell damage.
Pb may induce alterations in zinc containing proteins, including the known inhibitory effect …