Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death
Huntington's disease is caused by an abnormal polyglutamine expansion within the protein
huntingtin and is characterized by microscopic inclusion bodies of aggregated huntingtin …
huntingtin and is characterized by microscopic inclusion bodies of aggregated huntingtin …
Huntington and its role in neuronal degeneration
SH Li, XJ Li - The Neuroscientist, 2004 - journals.sagepub.com
Huntington's disease results from a polyglutamine expansion in the N-terminal region of
huntingtin (htt). This abnormality causes protein aggregation and leads to neurotoxicity …
huntingtin (htt). This abnormality causes protein aggregation and leads to neurotoxicity …
Neurotrophic factors in Huntington's disease
J Alberch, E Pérez-Navarro, JM Canals - Progress in brain research, 2004 - Elsevier
Huntington's disease is a neurodegenerative disorder characterized by the selective loss of
striatal neurons and, to a lesser extent, cortical neurons. The neurodegenerative process is …
striatal neurons and, to a lesser extent, cortical neurons. The neurodegenerative process is …
Brain-derived neurotrophic factor regulates the onset and severity of motor dysfunction associated with enkephalinergic neuronal degeneration in Huntington's …
JM Canals, JR Pineda, JF Torres-Peraza… - Journal of …, 2004 - Soc Neuroscience
The mechanism that controls the selective vulnerability of striatal neurons in Huntington's
disease is unclear. Brain-derived neurotrophic factor (BDNF) protects striatal neurons and is …
disease is unclear. Brain-derived neurotrophic factor (BDNF) protects striatal neurons and is …
Differential loss of striatal projection systems in Huntington's disease: a quantitative immunohistochemical study
YP Deng, RL Albin, JB Penney, AB Young… - Journal of chemical …, 2004 - Elsevier
Prior studies suggest differences exist among striatal projection neuron types in their
vulnerability to Huntington's disease (HD). In the present study, we immunolabeled the fibers …
vulnerability to Huntington's disease (HD). In the present study, we immunolabeled the fibers …
Turning the heterogeneous into homogeneous: studies on selectively isolated GABAergic interneuron subsets
The amazing morphological and electrophysiological diversity of cortical GABAergic
interneurons subserves the broad diversity of processes these cells modulate in neuronal …
interneurons subserves the broad diversity of processes these cells modulate in neuronal …
[图书][B] Adenoviral BDNF and Noggin cooperate to induce neuronal recruitment from endogenous progenitor cells in the adult mammalian forebrain
E Chmielnicki - 2004 - search.proquest.com
Overexpression of neuronal differentiation/survival factors and of inhibitors of glial
differentiation may direct neuronal recruitment from endogenous progenitors. Adenoviral …
differentiation may direct neuronal recruitment from endogenous progenitors. Adenoviral …
Die Huntingtonsche Krankheit
MM Rehm - 2004 - mediatum.ub.tum.de
In einer retrospektiven Querschnittstudie zur Huntingtonschen Krankheit im süddeutschen
Raum werden an 180 Patienten aus 168 Familien epidemiologische Daten zur Prävalenz …
Raum werden an 180 Patienten aus 168 Familien epidemiologische Daten zur Prävalenz …