Background Cleft lip or palate (or the two in combination) is a common birth defect that
results from a mixture of genetic and environmental factors. We searched for a specific …

Vitamin D receptor (VDR) polymorphisms have been associated with several immune-
related diseases, and VDR and vitamin D itself modulate T cell differentiation. VDR maps to …

Familial combined hyperlipidemia (FCHL), characterized by elevated levels of serum total
cholesterol, triglycerides or both,, is observed in about 20% of individuals with premature …

This well-organized and clearly written text has a unique focus on methods of identifying the
joint effects of genes and environment on disease patterns. It follows the natural sequence of …

Genome scans for asthma have identified suggestive or significant linkages on 17 different
chromosomes, including chromosome 12, region q13–23, housing the vitamin D receptor …

Rationale Recent investigation suggests that a reversible glutamatergically mediated
thalamocortical-striatal dysfunction may serve as a reliable pathophysiological and …

We provide a general purpose family‐based testing strategy for associating disease
phenotypes with haplotypes when phase may be ambiguous and parental genotype data …

Isolated or nonsyndromic cleft lip with or without cleft palate (CL/P) is a common birth defect
with a complex etiology. A 10-cM genome scan of 388 extended multiplex families with CL/P …

The central role of methylenetetrahydrofolate reductase (MTHFR) in the folate metabolism
renders MTHFR gene polymorphisms (C677T and A1298C) potential modulators of a variety …

Estimation and testing of genetic effects (genotype relative risks) are often performed
conditionally on parental genotypes, using data from case‐parent trios. This strategy avoids …