Cancer genetics is increasingly becoming integrated into the practice of modern medical
oncology. The ability to distinguish a growing proportion of the 5% to 10% of all cancers that …

Breast cancer in men is a rare disease, accounting for∼ 1% of all breast cancer cases.
Although the epidemiologic literature regarding female breast cancer is extensive, relatively …

Background: In BRCA2 mutation carriers, increased risks have been reported for several
cancer sites besides breast and ovary. As most of the families included in earlier reports …

A recent report estimated the breast cancer risks in carriers of the three Ashkenazi founder
mutations to be higher than previously published estimates derived from population based …

Background Several anthropometric measures have been found to be associated with the
risk of breast cancer. Current weight, body mass index, and adult weight gain appear to be …

Background Germline mutations in the BRCA1 and BRCA2 genes have been shown to
account for the majority of hereditary breast and ovarian cancers. The purpose of our study …

OBJECTIVE: Women at high risk of ovarian cancer are currently offered two options: either
surveillance or prophylactic bilateral salpingo-oophorectomy. The efficacy and outcome of …

Individuals carrying germline mutations in one allele of the BRCA1 or BRCA2 genes are at
significantly increased risk of developing cancer. Although the increased risk of breast …

Purpose: Mutations in BRCA1 or BRCA2 genes increase breast cancer risk. Assuring
reliability of information about these mutations is increasingly important to the health care …

Introduction Several genetic risk models for breast and ovarian cancer have been
developed, but their applicability to specific populations has not been evaluated. We used …