T-cell help for B cells is essential for high-affinity antibody responses and B-cell memory.
Recently, the identity of a discrete follicular population of T cells that has a crucial role in this …

Rheumatoid arthritis is a complex systemic disease that ultimately leads to the progressive
destruction of articular and periarticular structures. Novel data indicate that the innate …

Objective. To identify gene expression signatures in minor salivary glands (MSGs) from
patients with primary Sjögren's syndrome (SS). Methods. A 16K complementary DNA …

Rheumatoid arthritis is a common autoimmune disease with a complex genetic etiology.
Here we identify a SNP in the promoter region of FCRL3, a member of the Fc receptor-like …

Objective. Ectopic lymphoneogenesis can occur in the salivary glands of Sjögren's
syndrome (SS) patients and is associated with local antigen-driven B cell responses …

The cytokines B lymphocyte stimulator (BLyS) and a proliferation-inducing ligand (APRIL)
enhance autoimmune disease by sustaining B cell activation. In RA, B cells contribute to the …

CXCL13 and CCL21 have been functionally implicated in lymphoid tissue organization both
in the upstream phases of lymphoid tissue embryogenesis and in ectopic lymphoid …

B cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL) are members of
the tumour necrosis factor superfamily. We have examined circulating BAFF and APRIL in …

Rheumatoid arthritis (RA) is a chronic inflammatory disease leading to joint destruction (1).
In RA, migration of leukocytes into the synovial tissue (ST) occurs. These leukocytes and …

Immunohistochemical analysis revealed that the intimal lining cells of synovial tissue of
inflamed joints of patients with rheumatoid arthritis differed from that of normal joints or of …