Mast cells are critical for allergic reactions, but also for innate or acquired immunity and
inflammatory conditions that worsen by stress. Corticotropin-releasing hormone (CRH) …

The bladder urothelium exhibits dynamic sensory properties that adapt to changes in the
local environment. These studies investigated the localization and function of bradykinin …

Interstitial cystitis (IC) is a disorder of the uri-nary bladder characterized by urgency,
frequency, nocturia, and chronic pelvic pain. The main pathologic findings include …

Interstitial cystitis (IC) is a disorder of the urinary bladder characterized by urgency,
frequency, nocturia and suprapubic pain. IC occurs primarily in women and symptoms are …

According to Abdel-Mageed et al, an increased expression of p65, a nuclear factor-kappaB
subunit, was found in patients with PBS/IC. Interestingly, these authors subsequently …

Increased mast cell numbers and mast cell activation represent one of the prevalent
etiologic theories for interstitial cystitis, an inflammatory condition in the bladder. This study …

Chronic fatigue syndrome (CFS) is a complex disorder that has also been referred to as
''chronic mononucleosis,''''muscular encephalomyelitis,''1–3 ''neurasthenia,''and ''postviral …

A spatial association between mast cells and nerves has been described in both the
gastrointestinal and genitourinary tracts. However, the factors that influence the anatomic …

Interstitial cystitis (IC) is a syndrome consisting of severe refractory bladder symptoms of
unknown etiology. The disease tends to affect Caucasian women with a mean age of 40 …

Interstitial cystitis (IC) is an inflammatory bladder condition of unknown etiology. Tryptase
released from elevated numbers of activated mast cells is a proposed mediator of the …