The increased use of fluoroquinolones has led to increasing resistance to these
antimicrobials, with rates of resistance that vary by both organism and geographic region …

Quinolones are one of the largest classes of antimicrobial agents used worldwide. This
review considers the quinolones that are available currently and used widely in Europe …

Bacterial resistance to quinolones/fluoroquinolones has emerged rapidly and such
resistance has traditionally been attributed to the chromosomally mediated mechanisms that …

PURPOSE: To measure the achievable perioperative aqueous concentration of the
commercially available topically administered fourth generation fluoroquinolones …

Three hundred and seventeen non pregnant females, suffering of recurrent lower urinary
tract infections (UTIs; at least three episodes in the preceding 12 months) were enrolled in a …

Objectives: To measure the mutant prevention concentration (MPC) of ciprofloxacin for a set
of urinary tract infection (UTI) Escherichia coli isolates with different levels of susceptibility …

Fluoroquinolones are a class of synthetic antibacterial agents that were approved for ocular
therapy in 1991 and have become popular therapy for the treatment and prevention of …

Over the past 2 decades, antimicrobial resistance among Streptococcus pneumoniae, the
most common cause of community-acquired pneumonia (CAP), has escalated dramatically …

ABSTRACT Pradofloxacin (PRA) is an 8-cyano-fluoroquinolone (FQ) being developed to
treat bacterial infections in dogs and cats. Its mutant prevention concentrations (MPC) were …

Three pharmacodynamic models of increasing complexity, designed for two subpopulations
of bacteria with different susceptibilities, were developed to describe and predict the …