The free radical theory of aging postulates that the production of intracellular reactive
oxygen species is the major determinant of life span. Numerous cell culture, invertebrate …

Introduction 3. Reactive oxygen species in tumor growth and cellular survival 4. Reactive
oxygen species in cell motility and metastasis formation 5. Generation of reactive oxygen …

Human pharmacokinetics data indicate that iv ascorbic acid (ascorbate) in pharmacologic
concentrations could have an unanticipated role in cancer treatment. Our goals here were to …

Reactive oxygen species (ROS) are potent inducers of oxidative damage and have been
implicated in the regulation of specific cellular functions, including apoptosis. Mitochondrial …

Calorie restriction (CR) is the only experimental manipulation that is known to extend the
lifespan of a number of organisms including yeast, worms, flies, rodents and perhaps non …

Mitochondrial biogenesis and mitochondrial DNA (mtDNA) maintenance depend on
coordinated expression of genes in the nucleus and mitochondria. A variety of intracellular …

Nitric oxide is a bioactive molecule involved in many biological events that has been
reported as prooxidant as well as antioxidant in plants. In the present study, we evaluated …

Mitochondria produce nitric oxide (NO) through a Ca 2+-sensitive mitochondrial NO
synthase (mtNOS). The NO produced by mtNOS regulates mitochondrial oxygen …

Whereas the pathogenesis of atherosclerosis has been intensively studied and described,
the underlying events that initiate cardiovascular disease are not yet fully understood. A …

Overwhelming evidence has accumulated indicating that oxidative stress is a crucial factor
in the pathogenesis of neurodegenerative diseases. The major site of production of …