Most common diseases and many important quantitative traits are complex genetic traits,
with multiple genetic and environmental variables contributing to the observed phenotype …

Hepatocellular carcinoma (HCC) is a leading cause of cancer death world wide, accounting
for approximately 600,000 deaths per year [1–4]. In North America, Western Europe and …

Accessing and analyzing the exponentially expanding genomic sequence and functional
data pose a challenge for biomedical researchers. Here we describe an interactive system …

The innate immune system of mammals provides a rapid response to repel assaults from
numerous infectious agents including bacteria, viruses, fungi, and parasites. A major …

We mapped histone H3 lysine 4 di-and trimethylation and lysine 9/14 acetylation across the
nonrepetitive portions of human chromosomes 21 and 22 and compared patterns of lysine 4 …

12.1 Background A phylo-HMM can be thought of as a machine that probabilistically
generates a multiple alignment, column by column, such that each column is defined by a …

Sites of transcription of polyadenylated and nonpolyadenylated RNAs for 10 human
chromosomes were mapped at 5–base pair resolution in eight cell lines. Unannotated …

MicroRNAs (miRNAs) are∼ 22 nt-long non-coding RNA molecules, believed to play
important roles in gene regulation. We present a comprehensive analysis of the …

The HapMap Web site at http://www. hapmap. org is the primary portal to genotype data
produced as part of the International Haplotype Map Project. In phase I of the project,> 1.1 …

The quantitative analysis of biological sequence data is based on methods from statistics
coupled with efficient algorithms from computer science. Algebra provides a framework for …