Abnormal chromosome content—also known as aneuploidy—is the most common
characteristic of human solid tumours. It has therefore been proposed that aneuploidy …

Aging can be defined as progressive functional decline and increasing mortality over time.
Here, we review evidence linking aging to nuclear DNA lesions: DNA damage accumulates …

Disrupted passage through mitosis often leads to chromosome missegregation and the
production of aneuploid progeny. Aneuploidy has long been recognized as a frequent …

Cdc20 and Cdh1 are the activating subunits of the anaphase-promoting complex (APC), an
E3 ubiquitin ligase that drives cells into anaphase by inducing degradation of cyclin B and …

Proper chromosome segregation is required to maintain the appropriate number of
chromosomes from one cell generation to the next and to prevent aneuploidy, the condition …

Faithful chromosome segregation is essential for the maintenance of genetic stability during
cell division and it is at least partly monitored by the spindle checkpoint, a surveillance …

Genetic interventions that accelerate or retard aging in mice are crucial in advancing our
knowledge over mammalian aging. Yet determining if a given intervention affects the aging …

The spindle assembly checkpoint is a cellular surveillance mechanism that functions to
ensure faithful chromosome segregation during mitosis. Failure of this checkpoint can result …

The prevalence of osteoporosis is raising worldwide as improving conditions of living and
treatment of other common diseases continuously increases life expectancy. Thus …

The mitotic spindle assembly checkpoint ensures proper chromosome segregation during
mitosis by inhibiting the onset of anaphase until all kinetochores are attached to the mitotic …