In an era marked by the increasing prevalence of obesity, diabetes, and cardiovascular
disease, the nuclear receptor peroxisome proliferator-activated receptor γ (PPARγ) has …

The three peroxisome-proliferator-activated receptor (PPAR) subtypes, PPAR-γ, PPAR-α
and PPAR-δ, are nuclear receptors that have been the focus of extensive research during …

Mesenchymal stem cells (MSCs) are a pluripotent cell type that can differentiate into several
distinct lineages. Two key transcription factors, Runx2 and peroxisome proliferator–activated …

Adiponectin is secreted from adipocytes, and low circulating levels have been
epidemiologically associated with obesity, insulin resistance, type 2 diabetes, and …

Cell culture models have been developed to study commitment and subsequent
differentiation of preadipocytes into adipocytes. Bone morphogenetic protein 4 commits …

Peroxisome proliferator-activated receptor γ (PPARγ) is a nuclear receptor regulating an
array of diverse functions in a variety of cell types including regulation of genes associated …

Peroxisome proliferator-activated receptor-γ (PPARγ) is considered to be one of the master
regulators of adipocyte differentiation. PPARγ2 is abundantly expressed in mature …

The principal abnormalities of the metabolic syndrome are abdominal obesity, atherogenic
dyslipidemia, hypertension, insulin resistance, inflammation, and prothrombotic states. This …

Obesity and lipoatrophy are major risks for insulin resistance, non-insulin-dependent
diabetes and cardiovascular disease. In the past three decades, significant advances have …

Adipogenesis is the developmental process by which a multipotent mesenchymal stem cell
differentiates into a mature adipocyte. This process involves a highly regulated and …