The major histocompatibility complex (MHC) is a gene dense region found in all jawed
vertebrates examined to date. The MHC contains a high percentage of immune genes, in …

Celiac disease is a multifactorial disease with complex genetics. Both HLA and non-HLA
genes contribute to the genetic component, but recent findings suggest that the importance …

Much of what we know about the chromatin-based mechanisms that regulate gene
expression in mammals has come from the study of what are, paradoxically, atypical genes …

Some people inherit an unfortunate combination of genetic sequences, such that exposure
to an external trigger causes their immune response to turn on their own tissues. Although …

Autoimmune diseases are the result of an interplay between predisposing genes and
triggering environmental factors, leading to loss of self-tolerance and an immune-mediated …

In animals, it is the female that typically selects a mating partner. This decision can occur
before, during and after copulation. Here, recent evidence for the involvement of genes …

The MHC region contains several unique characteristics that set it apart as the most
important region in the vertebrate genome in relation to disease. Recent data fit with the long …

Autoimmune diseases, such as type 1 diabetes, rheumatoid arthritis, psoriasis and systemic
lupus erythematosus, affect approximately 4% of the population in industrialized countries …

Generalized vitiligo is a common, autoimmune, familial-clustering depigmentary disorder of
the skin and hair that results from selective destruction of melanocytes. Generalized vitiligo …

Background The genomic organisation of the Major Histocompatibility Complex (MHC)
varies greatly between different vertebrates. In mammals, the classical MHC consists of a …