Post‐translational proteolytic processing of the preproglucagon gene in the gut results in the
formation of glucagon‐like peptide 1 (GLP‐1). Owing to its glucose‐dependent …

Although there is abundant evidence that hyperglucagonaemia plays a key role in the
development of hyperglycaemia in type 2 diabetes, efforts to understand and correct this …

Glucagon-like peptide 1 (GLP-1), a gut incretin hormone that stimulates insulin secretion,
also activates antiapoptotic signaling pathways such as phosphoinositide 3-kinase and …

Context: First-phase insulin secretion (within 10 min after a sudden rise in plasma glucose)
is reduced in type 2 diabetes mellitus (DM2). The incretin mimetic exenatide has …

The actions of the structurally related proglucagon-derived peptides (PGDPs)—glucagon,
glucagon-like peptide (GLP)-1 and GLP-2—are focused on complementary aspects of …

Incretin hormones are defined as intestinal hormones released in response to nutrient
ingestion, which potentiate the glucose-induced insulin response. In humans, the incretin …

Glucagon-like peptide 1 (GLP-1) was discovered as an insulinotropic gut hormone,
suggesting a physiological role as an incretin hormone, ie, being responsible, in part, for the …

Abstract Aims Glucagon-like peptide-1 (GLP-1) is an insulinotropic hormone released from
the gut in response to nutrients. Besides its well-established direct effect on pancreatic beta …

The 'incretin effect'describes the phenomenon of an enhanced insulin response following
oral ingestion of glucose compared with that after intravenous administration of glucose …

Orally ingested glucose leads to a greater insulin response compared to intravenously
administered glucose leading to identical postprandial plasma glucose excursions, a …