Vascular inflammation is well known for its ability to compromise the function of the blood–
brain barrier (BBB). Whether inflammation on the parenchymal side of the barrier, such as …

The present study investigated whether thrombin, a potent microglial activator, can induce
reactive oxygen species (ROS) generation through activation of microglial NADPH oxidase …

Recent studies have begun to investigate the role of agrin in brain and suggest that agrin's
function likely extends beyond that of a synaptogenic protein. Particularly, it has been shown …

The original finding of Paul Ehrlich (1) that an infused dye did not stain the brain tissue,
together with the observation of his pupil Ernst Goldmann that the very same dye if applied …

There is a growing consensus that microvascular damage is an important contributing factor
to the pathogenesis of dementia (1). Increased vascular tortuosity and narrowing is a …

Clinical neuroscientists have focused increasing attention on white matter connections in the
brain and on the effects of aging and disease on these connections. Recent advances in …

The main neurodegenerative diseases can be loosely grouped into two broad categories—
memory disorders or 'dementias' such as Alzheimer's disease (AD) and movement disorders …

This chapter contains sections titled: Introduction Protein Folding and Glycosaminoglycans β
Sheets Proteoglycans Heparin, Heparan Sulfate and Other Glycosaminoglycans Heparin …