Impairments in certain cognitive functions, such as working memory, are core features of
schizophrenia. Convergent findings indicate that a deficiency in signalling through the TrkB …

The treatment of schizophrenia has evolved over the past half century primarily in the
context of antipsychotic drug development. Although there has been significant progress …

Background Pathomorphologic brain changes occurring as early as first-episode
schizophrenia have been extensively described. Longitudinal studies have demonstrated …

Dysfunction of inhibitory neurons in the prefrontal cortex (PFC), represented by decreased
expression of GABA-related genes such as the 67 kDa isoform of glutamate decarboxylase …

The reversible histone acetylation and deacetylation are epigenetic phenomena that play
critical roles in the modulation of chromatin topology and the regulation of gene expression …

Rationale Cortical γ-aminobutyric acid (GABA) ergic neurons contribute to the orchestration
of pyramidal neuron population firing as follows:(1) by releasing GABA on GABA A and …

It has become increasingly clear that the simple neurodevelopmental model fails to explain
many aspects of schizophrenia including the timing of the onset, and the nature of the …

While schizophrenia is generally considered a neurodevelopmental disorder, evidence for
progressive clinical deterioration and subtle neurostructural changes following the onset of …

Large-scale gene expression studies in schizophrenia (SZ) have generally focused on the
dorsolateral prefrontal cortex. Studies of other brain regions have been less frequent and …

Homer proteins are involved in the functional assembly of postsynaptic density proteins at
glutamatergic synapses and are implicated in learning, memory and drug addiction. Here …