Colorectal cancer is one of the most commonly diagnosed malignant diseases, with an
estimated 1,023,000 new cases and 529,000 deaths worldwide each year. This review …

Combination chemotherapy regimens including irinotecan and oxaliplatin markedly improve
response rate and prolong median survival over fluorouracil with leucovorin (FU/LV), and …

Purpose A traditional end point for colon adjuvant clinical trials is overall survival (OS), with
5 years demonstrating adequate follow-up. A shorter-term end point providing convincing …

Background:: Long-term survival is reported in patients with liver metastases of colorectal
cancer. Recently, an increased number of reports on liver resection following neoadjuvant …

Purpose Bevacizumab (Avastin; Genentech Inc, South San Francisco, CA), a recombinant,
humanized anti–vascular endothelial growth factor monoclonal antibody that inhibits tumor …

Purpose Most patients with colorectal liver metastases present to general surgeons and
oncologists without a specialist interest in their management. Since treatment strategy is …

Background Therapeutic advances for patients with metastatic colorectal cancer (CRC) have
been associated with prolonged survival. This study was undertaken to test the hypothesis …

Abstract Learning Objectives After completing this course, the reader will be able to:
Describe the evolution of cancer chemotherapy for patients with colorectal cancer. Discuss …

Abstract Learning Objectives After completing this course, the reader will be able to: Identify
the advantages and disadvantages of the various chemotherapeutic regimens used to treat …

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