Systemic adjuvant chemotherapy has played a major role in improving the prognosis of
patients who have breast cancer. Studies have shown that 5-year, disease-free survival …

Breast cancer prevention research has made remarkable progress in the past decade. Much
of this progress has come from clinical trials. However, in the future to test the many …

Aims and background p53, c-erbB-2 and Ki-67 protein expression and microvessel density
(MVD) determined by CD34 antibody were evaluated by immunohistochemistry and their …

Li-Fraumeni syndrome and the LF-like syndrome, rare heritable conditions that predispose
to the development of malignancy, are associated with germline mutations of the tumor …

Abstract Purpose: Her-2/neu and p53-mediated signalling have been shown to interact at
various cellular levels. However, the clinical relevance of p53 alterations in patients …

Regulatory sequences derived from the rat whey acidic protein gene have been used to
preferentially overexpress a murine 172Arg--> Leu mutant p53 in the mammary gland of …

Page 1 ABSTRACT HOULE, CHRISTOPHER DAVID. Cooperative Effects of Tumor Suppressor
Genes and Oncogenes on the Dynamic Process of Tumorigenesis. (Under the direction of Dr …

There is significant evidence that indicates an increased risk for developing secondary lung
cancer in women treated with radiotherapy for breast cancer and an additional risk for …

Women with breast cancer are at increased risk for developing a second primary tumor in
the lung. There may be a greater risk for women who receive radiotherapy and smoke. 110 …