Polyphenols are wide variety of compounds that occur in fruits and vegetables, wine, tea,
extra virgin olive oil, chocolate and other cocoa products. Several polyphenols have been …

Cytochromes P450 are responsible for metabolism of most xenobiotics and are required for
the efficient elimination of foreign chemicals from the body. Paradoxically, these enzymes …

Plants have evolved complex regulatory mechanisms in adapting to various environmental
stresses. One of the consequences of many stresses is an increase in the cellular …

Ultraviolet B (UVB) irradiation of skin induces an acute inflammation. Cyclooxygenase-2
(COX-2) protein plays key roles in acute inflammation in UVB-irradiated keratinocyte cell line …

Objective—We tested the hypothesis that p47phox associates with the actin cytoskeleton,
enabling site-directed activation of NAD (P) H oxidase, and assessed whether these actions …

The extracellular matrix (ECM) facilitates pancreatic cancer cells survival, which is of central
importance for pancreatic adenocarcinoma that is highly fibrotic. Here, we show that reactive …

Diallyl disulfide (DADS), an oil soluble constituent of garlic (Allium sativum), has been
reported to cause antimutagentic and anticarcinogenic effects in vitro and in vivo by …

We have disrupted expression of the mitochondrial Friedreich ataxia protein frataxin
specifically in murine hepatocytes to generate mice with impaired mitochondrial function and …

Heme oxygenase-1 (HO-1) is a key cytoprotective enzyme and an established marker of
oxidative stress. Increased HO-1 expression has been found in the resident macrophages in …

Nerve growth factor (NGF) regulates the nociceptive properties of a subset of small diameter
sensory neurons by increasing the expression of the heat‐sensing transient receptor …