Histone deacetylases (HDACs) are considered to be among the most promising targets in
drug development for cancer therapy, and first-generation histone deacetylase inhibitors …

Sir2 is an NAD-dependent deacetylase that connects metabolism with longevity in yeast,
worms and flies. Mammals contain seven homologs of yeast Sir2, SIRT1–7. Here, we review …

The Sir2 histone deacetylase functions as a chromatin silencer to regulate recombination,
genomic stability, and aging in budding yeast. Seven mammalian Sir2 homologs have been …

Background Recently, a small population of cancer stem cells in adult and pediatric brain
tumors has been identified. Some evidence has suggested that CD133 is a marker for a …

Acetylation of proteins on lysine residues is a dynamic posttranslational modification that is
known to play a key role in regulating transcription and other DNA-dependent nuclear …

As sensors for fat-soluble hormones and dietary lipids, oscillations in nuclear receptor (NR)
expression in key metabolic tissues may contribute to circadian entrainment of nutrient and …

Resveratrol, a natural phytoalexin found in grapes and red wine [1], increases longevity in
the short-lived invertebrates Caenorhabditis elegans and Drosophila [2–5] and exerts a …

Since poly-ADP ribose was discovered over 40 years ago, there has been significant
progress in research into the biology of mono-and poly-ADP-ribosylation reactions. During …

Sirtuins are a family of NAD+-dependent protein deacetylases widely distributed in all phyla
of life. Accumulating evidence indicates that sirtuins are important regulators of organism life …

Sir2 and insulin/IGF-1 are the major pathways that impinge upon aging in lower organisms.
In Caenorhabditis elegans a possible genetic link between Sir2 and the insulin/IGF-1 …