17β-Estradiol (E2) controls many aspects of human physiology, including development,
reproduction and homeostasis, through regulation of the transcriptional activity of its cognate …

The Tip60 histone acetyltransferase is part of an evolutionarily conserved multisubunit
complex, NuA4, which is recruited by many transcription factors to their target promoters …

The molecular machinery that governs circadian rhythmicity comprises proteins whose
interplay generates time-specific transcription of clock genes. The role of chromatin …

SIRT1 and other NAD-dependent deacetylases have been implicated in control of cellular
responses to stress and in tumorigenesis through deacetylation of important regulatory …

We previously showed that Arabidopsis thaliana histone acetyltransferase TAF1/HAF2 is
required for the light regulation of growth and gene expression, and we show here that …

Introduction p53 protein was first identified in 1979 as a transformation-related protein [1]
and a cellular protein which accumulates in the nuclei of cancer cells and binds tightly to the …

Genetic information is packaged in the highly dynamic nucleoprotein structure called
chromatin. Many biological processes are regulated via post-translational modifications of …

Summary The Saccharomyces cerevisiae Elongator complex consisting of the six Elp1–Elp6
proteins has been proposed to participate in three distinct cellular processes: transcriptional …

Background Post-translational modification of histones resulting in chromatin remodelling
plays a key role in the regulation of gene expression. Here we report characteristic patterns …

Studies of the genetic regulation involved in drug metabolizing enzymes and drug
transporters are of great interest to understand the molecular mechanisms of drug response …