In this article we discuss relevant data on aging, longevity, and gender with particular focus
on inflammation gene polymorphisms which could affect an individual's chance to reach the …

Throughout embryonic and early postnatal development, the mammalian epididymis
changes from a straight tube to a highly coiled, complex duct that links the efferent ducts to …

Many epidemiological data indicate the presence of a strong familial component of longevity
that is largely determined by genetics, and a number of possible associations between …

Several alterations in immune function and a concomitant progressive increase in pro-
inflammatory status are the major characteristics of ageing process. Cytokines play a key …

During aging, the thymus undergoes a marked involution that is responsible for profound
changes in the T‐cell compartment. To investigate the capacity of the thymus to produce …

Immunosenescence is characterized by three main aspects:(i) the shrinkage of the T cell
repertoire and the accumulation of oligoclonal expansions (megaclones) of memory/effector …

In no species other than humans do cultural, social, and biological factors interact with each
other in modulating complex phenotypes. Thus, the identification of genetic factors that affect …

Objective: We aimed to investigate the influence of the genetic variability of candidate genes
on survival at old age in good health. Methods: First, on the basis of a synthetic survival …

Immunosenescence features, such as thymic involution, alteration of T-cell repertoire,
autoimmunity and accumulation of memory/effector T cells, may be the result, at least in part …

Publisher Summary There is substantial evidence in the literature that suggests that genetic
influences remain important and substantially stable with aging, although there may be …