The adequacy of sample size is important to clinical trials. In the planning phase of a trial,
however, the investigators are often quite uncertain about the sizes of parameters which are …

ContextWhen unfractionated heparin is used to treat acute venous thromboembolism, it is
usually administered by intravenous infusion with coagulation monitoring, which requires …

Noninferiority/equivalence designs are often used in vaccine clinical trials. The goal of these
designs is to demonstrate that a new vaccine, or new formulation or regimen of an existing …

BACKGROUND: Rotavirus gastroenteritis, which causes substantial infant mortality and
morbidity worldwide, is a vaccine-preventable disease. The purpose of this study was to …

Background Rectal budesonide is an effective treatment of active ulcerative proctitis or
proctosigmoiditis. Aim To compare the therapeutic efficacy, tolerability and safety, and …

The aim of this prospective, randomized, double-blind, double-dummy, multicenter clinical
trial was to investigate the efficacy and safety of PRO 160/120 (Prostagutt® forte), a fixed …

ABSTRACT A randomized, double-blind, double-dummy trial was performed comparing 200
mg of cefditoren-pivoxil twice daily for 5 days versus standard cefuroxime-axetil treatment …

Background There are no comparative studies of coated mesalazine. Aim To compare the
efficacy and tolerability of Eudragit‐L‐and ethylcellulose‐coated mesalazine tablets in …

Introduction: Retapamulin is a novel, topical antibacterial of the pleuromutilin class in
development for the treatment of secondarily infected traumatic lesions of the skin. Methods …

The standard approach for analysing a randomized clinical trial is based on intent‐to‐treat
(ITT) where subjects are analysed according to their assigned treatment group regardless of …