It is generally assumed that combinations of polymorphic alleles of different genes contribute
to polygenetic disorders. Variants of the opioid receptors are the obvious candidates …

Alcohol dependence is one of the leading causes of morbidity worldwide, yet only a minority
of those afflicted engages in treatment. While increasing access to treatment is an important …

INTRODUCTION: The μ-opioid receptor has been implicated in the pathogenesis of
dependence on opioids, alcohol, nicotine, and cocaine. Studies examining the association …

We examined 13 single nucleotide polymorphisms (SNPs) spanning the coding region of
the µ-opioid receptor gene (OPRM1), among 382 European Americans (EAs) affected with …

A polymorphism in the mu-opioid receptor (MOR)(A118G) has been shown to increase β-
endorphin binding affinity, theoretically placing greater inhibitory tone on hypothalamic …

Rationale The endogenous opioid system has been implicated in substance abuse and
response to pharmacotherapies for nicotine and alcohol addiction. We examined (1) the …

The gene encoding the mu-opioid receptor (OPRM1) is reported to be associated with a
range of substance dependence. Experiments in knockout mice indicate that the mu-opioid …

The authors sought to investigate the role of a common single nucleotide polymorphism in
the μ-opioid receptor gene (OPRM1) 118A> G for nociceptive sensory processing using …

BLOOD glucose has only recently emerged as an important variable in critical care. In the
past, this biologic marker has been largely ignored or considered as adaptive to the stress …

Twin, family, and adoption studies show that genetic factors play a signi. cant role in
vulnerability to becoming addicted to drugs. Through a combination of genetic approaches …