Recent analyses of sequence and microarray data have suggested that alternative splicing
plays a major role in the generation of proteomic and functional diversity in metazoan …

Understanding complex functional mechanisms requires the global and parallel analysis of
different cellular processes. DNA microarrays have become synonymous with this kind of …

The quadruplex structures formed by guanine-rich nucleic acid sequences have received
significant attention recently because of growing evidence for their role in important …

Although it is known that the human genome contains hundreds of microRNA (miRNA)
genes and that each miRNA can regulate a large number of mRNA targets, the overall effect …

Abstract Myotonic dystrophy type 1 (DM1) is caused by a CTG expansion mutation located in
the 3′ untranslated portion of the dystrophica myotonin protein kinase gene. The …

Human alternative isoform, cryptic, skipped, and constitutive splice sites from the
ALTEXTRON database were analysed regarding splice site strength, composition, GC …

Carrier-mediated transporters play a critical role in xenobiotic disposition and transporter
research is complicated by species differences and their selective tissue expression. The …

The post-transcriptional modification of mammalian transcripts by A-to-I RNA editing has
beenrecognized as an important mechanism for the generation of molecular diversity and …

Intron density in eukaryote genomes varies by more than three orders of magnitude, so there
must have been extensive intron gain and/or intron loss during evolution. A favored and …

Genome-wide analyses of alternative splicing have established its nearly ubiquitous role in
gene regulation in many organisms. Genome sequencing and comparative genomics have …