Understanding complex functional mechanisms requires the global and parallel analysis of different cellular processes. DNA microarrays have become synonymous with this kind of …
O Kikin, L D'Antonio, PS Bagga - Nucleic acids research, 2006 - academic.oup.com
The quadruplex structures formed by guanine-rich nucleic acid sequences have received significant attention recently because of growing evidence for their role in important …
Although it is known that the human genome contains hundreds of microRNA (miRNA) genes and that each miRNA can regulate a large number of mRNA targets, the overall effect …
Abstract Myotonic dystrophy type 1 (DM1) is caused by a CTG expansion mutation located in the 3′ untranslated portion of the dystrophica myotonin protein kinase gene. The …
Human alternative isoform, cryptic, skipped, and constitutive splice sites from the ALTEXTRON database were analysed regarding splice site strength, composition, GC …
K Bleasby, JC Castle, CJ Roberts, C Cheng… - Xenobiotica, 2006 - Taylor & Francis
Carrier-mediated transporters play a critical role in xenobiotic disposition and transporter research is complicated by species differences and their selective tissue expression. The …
S Maas, Y Kawahara, KM Tamburro, K Nishikura - RNA biology, 2006 - Taylor & Francis
The post-transcriptional modification of mammalian transcripts by A-to-I RNA editing has beenrecognized as an important mechanism for the generation of molecular diversity and …
Intron density in eukaryote genomes varies by more than three orders of magnitude, so there must have been extensive intron gain and/or intron loss during evolution. A favored and …
Y Xing, C Lee - Nature Reviews Genetics, 2006 - nature.com
Genome-wide analyses of alternative splicing have established its nearly ubiquitous role in gene regulation in many organisms. Genome sequencing and comparative genomics have …