Inherited germline mutations in either BRCA1 or BRCA2 confer a significant lifetime risk of
developing breast or ovarian cancer. Defining how these two genes function at the cellular …

The process of ubiquitylation is best known for its role in targeting proteins for degradation
by the proteasome. However, recent studies of DNA-repair and DNA-damage-response …

Uch37 is one of the three principal deubiquitinating enzymes (DUBs), and the only ubiquitin
carboxy-terminal hydrolase (UCH)-family protease, that is associated with mammalian …

The heterodimeric tumor-suppressor complex BRCA1/BARD1 exhibits E3 ubiquitin ligase
activity and participates in cell proliferation and chromosome stability control by incompletely …

The N-terminus of the Br east Ca ncer-1 predisposition protein (BRCA1) associates with the
B RCA1-a ssociated R ING d omain-1 protein (BARD1) to form a heterodimer, which exhibits …

TGF-β (transforming growth factor-β) signals through serine/threonine kinase receptors and
intracellular Smad transcription factors. An important regulatory step involves specific …

Approximately 5–10% of breast carcinomas and 10% of ovarian carcinomas are ascribable
to a genetic susceptibility. Of these, about 40% are related to genetic mutations in the genes …

Approximately 10% of the cases of breast cancer and invasive ovarian cancer are
hereditary, occurring predominantly in women with germ-line mutations in the BRCA1 or …

hBRCA1 and hBARD1 are tumor suppressor proteins that are involved as heterodimer via
ubiquitinylation in many cellular processes, such as DNA repair. Loss of BRCA1 or BARD1 …

Discovering the precise function of the breast and ovarian specific tumor suppressor,
BRCA1, has proven to be quite complicated. It has been determined that BRCA1, together …