PSA-NCAM in mammalian structural plasticity and neurogenesis

L Bonfanti - Progress in neurobiology, 2006 - Elsevier
Polysialic acid (PSA) is a linear homopolymer of α2-8-N acetylneuraminic acid whose major
carrier in vertebrates is the neural cell adhesion molecule (NCAM). PSA serves as a potent …

Polysialylated neural cell adhesion molecule is involved in induction of long-term potentiation and memory acquisition and consolidation in a fear-conditioning …

O Senkov, M Sun, B Weinhold… - Journal of …, 2006 - Soc Neuroscience
Polysialic acid (PSA) regulates functions of the neural cell adhesion molecule (NCAM)
during development and in neuroplasticity in the adult; the underlying mechanisms at …

Metalloprotease‐induced ectodomain shedding of neural cell adhesion molecule (NCAM)

CL Hinkle, S Diestel, J Lieberman… - Journal of …, 2006 - Wiley Online Library
Transmembrane forms of neural cell adhesion molecule (NCAM140, NCAM1801) are key
regulators of neuronal development. The extracellular domain of NCAM can occur as a …

N-cadherin transsynaptically regulates short-term plasticity at glutamatergic synapses in embryonic stem cell-derived neurons

K Jüngling, V Eulenburg, R Moore… - Journal of …, 2006 - Soc Neuroscience
The cell adhesion molecule N-cadherin has been proposed to regulate synapse formation in
mammalian central neurons. This is based on its synaptic localization enabling alignment of …

Is sialic acid in milk food for the brain?

M Karim, WB Wang Bing - CABI Reviews, 2006 - cabidigitallibrary.org
The rapid brain growth of infants places exceptionally high demands on the supply of
nutrients from the diet. Human milk is the best source of food for brain growth and cognition …

Neural cell adhesion molecule-associated polysialic acid inhibits NR2B-containing N-methyl-D-aspartate receptors and prevents glutamate-induced cell death

MSL Hammond, C Sims, K Parameshwaran… - Journal of Biological …, 2006 - ASBMB
The neural cell adhesion molecule (NCAM) and its associated glycan polysialic acid play
important roles in the development of thenervoussystemandN-methyl-d-aspartate (NMDA) …

Hippocampal up‐regulation of NCAM expression and polysialylation plays a key role on spatial memory

C Venero, AI Herrero, K Touyarot… - European Journal of …, 2006 - Wiley Online Library
Memory formation has been associated with structural and functional modifications of
synapses. Cell adhesion molecules are prominent modulators of synaptic plasticity. Here …

In vivo synaptic plasticity in the dentate gyrus of mice deficient in the neural cell adhesion molecule NCAM or its polysialic acid

L Stoenica, O Senkov… - European Journal of …, 2006 - Wiley Online Library
The neural cell adhesion molecule NCAM and its associated polysialic acid (PSA) play
important roles in synaptic plasticity in the CA1 and/or CA3 regions of the hippocampus in …

Embryonic stem cell-derived neuronally committed precursor cells with reduced teratoma formation after transplantation into the lesioned adult mouse brain

M Dihné, C Bernreuther, C Hagel, KO Wesche… - Stem …, 2006 - academic.oup.com
The therapeutic potential of embryonic stem (ES) cells in neurodegenerative disorders has
been widely recognized, and methods are being developed to optimize culture conditions …

Mid-life stress and cognitive deficits during early aging in rats: individual differences and hippocampal correlates

C Sandi, K Touyarot - Neurobiology of aging, 2006 - Elsevier
We explored here the possibility that mid-life stress in rats could have deleterious effects on
cognitive abilities during early aging, as well as the potential role of inter-individual …