The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes

DJ Drucker, MA Nauck - The Lancet, 2006 - thelancet.com
Summary Glucagon-like peptide 1 (GLP-1) is a gut-derived incretin hormone that stimulates
insulin and suppresses glucagon secretion, inhibits gastric emptying, and reduces appetite …

The biology of incretin hormones

DJ Drucker - Cell metabolism, 2006 - cell.com
Gut peptides, exemplified by glucagon-like peptide-1 (GLP-1) and glucose-dependent
insulinotropic polypeptide (GIP) are secreted in a nutrient-dependent manner and stimulate …

Hyperinsulinemic hypoglycemia after gastric bypass surgery is not accompanied by islet hyperplasia or increased β-cell turnover

JJ Meier, AE Butler, R Galasso, PC Butler - Diabetes care, 2006 - Am Diabetes Assoc
OBJECTIVE—The purpose of this study was to establish whether hypoglycemia after gastric
bypass surgery (GBS) for morbid obesity is due to increased fractional β-cell area or …

Dipeptidyl peptidase IV inhibitors: a promising new therapeutic approach for the management of type 2 diabetes

CF Deacon, JJ Holst - The International Journal of Biochemistry & Cell …, 2006 - Elsevier
Glucagon-like peptide-1 is an insulinotropic hormone with antidiabetic potential due to its
spectrum of effects, which include glucose-dependent stimulation of insulin and inhibition of …

The glucagon-like peptide-1 metabolite GLP-1-(9–36) amide reduces postprandial glycemia independently of gastric emptying and insulin secretion in humans

JJ Meier, A Gethmann, MA Nauck… - American Journal …, 2006 - journals.physiology.org
Glucagon-like peptide 1 (GLP-1) lowers glycemia by modulating gastric emptying and
endocrine pancreatic secretion. Rapidly after its secretion, GLP-1-(7–36) amide is degraded …

Exenatide: a GLP-1 receptor agonist as novel therapy for Type 2 diabetes mellitus

M Briones, M Bajaj - Expert opinion on pharmacotherapy, 2006 - Taylor & Francis
Exenatide is a glucagon-like peptide 1 receptor agonist, which has recently received FDA
approval in the US for the treatment of Type 2 diabetes. Exenatide is an incretin mimetic that …

Discovery, structure− activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase …

Z Pei, X Li, K Longenecker… - Journal of medicinal …, 2006 - ACS Publications
A series of (5-substituted pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidine (C5-Pro-Pro)
analogues was discovered as dipeptidyl peptidase IV (DPPIV) inhibitors as a potential …

Glucagon: the effects of its excess and deficiency on insulin action

CG Fanelli, F Porcellati, P Rossetti, GB Bolli - Nutrition, metabolism and …, 2006 - Elsevier
AIM: To review the role that glucagon plays in physiology, physiopathology and clinical
medicine. DATA SYNTHESIS: Glucagon assays employing specific radioimmunoassay …

New insights into glucose regulation

DF Kruger, CL Martin, CE Sadler - The Diabetes Educator, 2006 - journals.sagepub.com
This review article describes the regulation of glucose homeostasis in subjects with and
without diabetes based on the emergence of new information and discusses modes of …

Effect of nutrient ingestion on total-body and splanchnic cortisol production in humans

R Basu, R Singh, A Basu, CM Johnson, RA Rizza - Diabetes, 2006 - Am Diabetes Assoc
The splanchnic bed produces cortisol at rates approximating extraadrenal tissues by
converting cortisone to cortisol via the 11β-hydroxysteroid dehydrogenase (11β-HSD) type 1 …