At a time of unprecedented expansion in the life sciences, evolution is the one theory that
transcends all of biology. Any observation of a living system must ultimately be interpreted in …

The complex, constantly evolving and multifaceted nature of cancer has made it difficult to
identify unique molecular and pathophysiological signatures for each disease variant …

The intracellular and extracellular dynamics that govern tumor growth and invasiveness in
vivo remain poorly understood. Cell genotype and phenotype, and nutrient, oxygen, and …

Abstract Background and Objectives Multicell spheroids (MCSs) represent a simple in vitro
system ideally suited for studying the effects of a wide variety of investigational treatments …

Mathematical modeling of both tumor growth and angiogenesis have been active areas of
research for the past several decades. Such models can be classified into one of two …

A comprehensive continuum model of solid tumor evolution and development is investigated
in detail numerically, both under the assumption of spherical symmetry and for arbitrary two …

An advantage of using level set methods for moving boundary problems is that geometric
quantities such as curvature can be readily calculated from the level set function. However …

Although the clinical arsenal in treating cancer has been greatly extended in recent years
with the application of new drugs and therapeutic modalities, the three basic approaches …

Within recent decades, quickening research and development of liposomal and nanoparticle
delivery systems has made Paul Ehrlich's dream of zauberkugeln–therapeutic magic bullets …

Cancer has become the leading cause of death for Americans. The development of
prognostic tools could have immediate impact on the lives of millions of cancer patients. We …