Many structurally diverse chemicals (eg, acrylamide, 2, 4-dithiobiuret, methylmercury) are
electrophiles and cause synaptic dysfunction by unknown mechanisms. The purpose of this …

This review provides an overview of the formation, pharmacology, and toxicology of
endogenous glutathione (GSH)-adducts with particular emphasis on GSH-adducts that arise …

Glutathione represents the major low molecular weight antioxidant redox recycling thiol in
mammalian cells and plays a central role in the cellular defence against oxidative damage …

The most reliable and robust risk factor for some neurodegenerative diseases is aging. It has
been proposed that processes of aging are associated with the generation of reactive …

Oxidative stress is considered to be one of the important mechanisms involved in
carcinogenesis. In our previous study, gadolinium endohedral metallofullerenol ([Gd@ C82 …

Glutathione (GSH) is a major component of the antioxidant defence system of mammalian
cells and is found in subcellular pools within the cytoplasm, nucleus and mitochondria. To …

OBJECTIVES: Oral and systemic cells are permanently exposed to various types of
xenobiotics, such as dental restorative materials, which may subsequently cause adverse …

Thioredoxin reductase (TrxR) reduces thioredoxin (Trx), thereby contributing to cellular
redox balance, facilitating the synthesis of deoxy-ribose sugars for DNA synthesis, and …

Glutamate-induced oxidative toxicity is mediated by glutathione depletion in the HT22
mouse hippocampal cell line. Previous results with pharmacological agents implicated the …

Hypochlorous acid (HOCl) and chloramines are produced by the neutrophil enzyme,
myeloperoxidase. Both react readily with thiols, although chloramines differ from HOCl in …