A number of proteins are activated by stress stimuli but none so spectacularly or with the
degree of complexity as the tumour suppressor p53 (human p53 gene or protein). Once …

The p53 tumor suppressor protein is a DNA sequence-specific transcriptional regulator that,
in response to various forms of cellular stress, controls the expression of numerous genes …

Upon DNA damage and other types of stress, p53 induces either cell-cycle arrest or
apoptosis depending on the cellular context. However, the molecular mechanisms that …

Human SIRT1 is an enzyme that deacetylates the p53 tumor suppressor protein and has
been suggested to modulate p53-dependent functions including DNA damage-induced cell …

Introduction p53 protein was first identified in 1979 as a transformation-related protein [1]
and a cellular protein which accumulates in the nuclei of cancer cells and binds tightly to the …

Generally, histone deacetylase (HDAC) inhibitor-induced p21Waf1/Cip1 expression is
thought to be p53 independent. Here we found that an inhibitor of HDAC, depsipeptide …

Interferons are cytokines with potent antiviral and antiproliferative activities. We report that
although a transient exposure to β-interferon induces a reversible cell cycle arrest, a …

The NAD-dependent histone deacetylase Sir2 plays a key role in connecting cellular
metabolism with gene silencing and aging. The androgen receptor (AR) is a ligand …

Summary p53 is regulated by multiple posttranslational modifications, including Hdm2-
mediated ubiquitylation that drives its proteasomal degradation. Here, we identify the p53 …

Summary von Hippel-Lindau (VHL) disease is a rare autosomal dominant cancer syndrome.
Although hypoxia-inducible factor-α (HIFα) is a well-documented substrate of von Hippel …