Monocytes are established circulating precursors for tissue macrophages and dendritic cells
(DCs). Monocyte-derived macrophages and DCs fulfill critical roles in innate and adaptive …

Acetaminophen (APAP) hepatotoxicity is currently the single most important cause of acute
liver failure in the US, and is associated with a significant number of deaths. The toxic …

Matrix metalloprotease type 9 (MMP-9) has been functionally implicated in VEGF activation,
the induction and maintenance of chronic angiogenesis, and early stage tumor growth in a …

Langerhans cells (LCs) are the only dendritic cells of the epidermis and constitute the first
immunological barrier against pathogens and environmental insults. The factors regulating …

Background & Aims: In searching for effects of acetaminophen (APAP) on hepatocytes
downstream of its metabolism that may participate in hepatotoxicity, we examined the role of …

Vascular remodeling in chronic hypoxic pulmonary hypertension includes marked
fibroproliferative changes in the pulmonary artery (PA) adventitia. Although resident PA …

The nature of dendritic cell (s)(DC [s]) that conditions efficient in vivo priming of CD8+ CTL
after immunization via epithelial tissues remains largely unknown. Here, we show that …

purpose. The role of microglia, present in the retina early in development before
vascularization, remains ill defined. The authors investigated whether microglia are …

Background. Although neutrophils and T cells are important in mediating renal injury
following ischaemia/reperfusion, the role of macrophages is still unknown. Using liposomal …

The study evaluates the influence of monocytes/macrophages in the mechanisms of skeletal
muscle injury using a mouse model and selective depletion of peripheral monocyte with …