A Barnett - International journal of clinical practice, 2006 - Wiley Online Library
Summary The dipeptidyl peptidase 4 (DPP‐4) inhibitors enhance the body's own ability to control blood glucose by increasing the active levels of incretin hormones in the body. Their …
AJ Bergman, C Stevens, YY Zhou, B Yi, M Laethem… - Clinical …, 2006 - Elsevier
BACKGROUND:: Dipeptidyl peptidase-IV (DPP-IV) inhibitorsrepresent a new class of oral antihyperglycemic agents. Sitagliptin is an orally active and selective DPP-IV inhibitor …
The incretin hormones are intestinal polypeptides that enhance postprandial insulin secretion. Gastric inhibitory polypeptide (GIP) was initially thought to regulate gastric acid …
J Ryskjær, CF Deacon, RD Carr… - European journal of …, 2006 - academic.oup.com
Abstract Objective Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide are incretin hormones, secreted in response to meal ingestion. The incretin …
Type 2 diabetes is characterized by hyperglycemia resulting from insulin resistance in the setting of inadequate β-cell compensation. Currently available therapeutic agents lower …
Monounsaturated fatty acids, such as oleic acid (OA), and certain milk proteins, especially whey protein (WP), have insulinotropic effects and can reduce postprandial glycemia. This …
DD De León, MF Crutchlow, JYN Ham… - The international journal …, 2006 - Elsevier
Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted from enteroendocrine L cells in response to ingested nutrients. The first recognized and most important action of …
CF Deacon, JJ Holst - The International Journal of Biochemistry & Cell …, 2006 - Elsevier
Glucagon-like peptide-1 is an insulinotropic hormone with antidiabetic potential due to its spectrum of effects, which include glucose-dependent stimulation of insulin and inhibition of …
MC Riddle, DJ Drucker - Diabetes care, 2006 - Am Diabetes Assoc
Current therapies for type 2 diabetes are frequently associated with inadequate control of postprandial hyperglycemia, weight gain, and, in the case of oral agents, loss of efficacy …