The incretin system: glucagon-like peptide-1 receptor agonists and dipeptidyl peptidase-4 inhibitors in type 2 diabetes

DJ Drucker, MA Nauck - The Lancet, 2006 - thelancet.com
Summary Glucagon-like peptide 1 (GLP-1) is a gut-derived incretin hormone that stimulates
insulin and suppresses glucagon secretion, inhibits gastric emptying, and reduces appetite …

DPP‐4 inhibitors and their potential role in the management of type 2 diabetes

A Barnett - International journal of clinical practice, 2006 - Wiley Online Library
Summary The dipeptidyl peptidase 4 (DPP‐4) inhibitors enhance the body's own ability to
control blood glucose by increasing the active levels of incretin hormones in the body. Their …

Pharmacokinetic and pharmacodynamic properties of multiple oral doses of sitagliptin, a dipeptidyl peptidase-IV inhibitor: a double-blind, randomized, placebo …

AJ Bergman, C Stevens, YY Zhou, B Yi, M Laethem… - Clinical …, 2006 - Elsevier
BACKGROUND:: Dipeptidyl peptidase-IV (DPP-IV) inhibitorsrepresent a new class of oral
antihyperglycemic agents. Sitagliptin is an orally active and selective DPP-IV inhibitor …

Glucagon-like peptide-1: from extract to agent. The Claude Bernard Lecture, 2005

JJ Holst - Diabetologia, 2006 - Springer
The incretin hormones are intestinal polypeptides that enhance postprandial insulin
secretion. Gastric inhibitory polypeptide (GIP) was initially thought to regulate gastric acid …

Plasma dipeptidyl peptidase-IV activity in patients with type-2 diabetes mellitus correlates positively with HbAlc levels, but is not acutely affected by food intake

J Ryskjær, CF Deacon, RD Carr… - European journal of …, 2006 - academic.oup.com
Abstract Objective Glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic
polypeptide are incretin hormones, secreted in response to meal ingestion. The incretin …

Therapeutic approaches to preserve islet mass in type 2 diabetes

LL Baggio, DJ Drucker - Annu. Rev. Med., 2006 - annualreviews.org
Type 2 diabetes is characterized by hyperglycemia resulting from insulin resistance in the
setting of inadequate β-cell compensation. Currently available therapeutic agents lower …

Glucose-induced incretin hormone release and inactivation are differently modulated by oral fat and protein in mice

PT Gunnarsson, MS Winzell, CF Deacon… - …, 2006 - academic.oup.com
Monounsaturated fatty acids, such as oleic acid (OA), and certain milk proteins, especially
whey protein (WP), have insulinotropic effects and can reduce postprandial glycemia. This …

Role of glucagon-like peptide-1 in the pathogenesis and treatment of diabetes mellitus

DD De León, MF Crutchlow, JYN Ham… - The international journal …, 2006 - Elsevier
Glucagon-like peptide-1 (GLP-1) is an incretin hormone secreted from enteroendocrine L
cells in response to ingested nutrients. The first recognized and most important action of …

Dipeptidyl peptidase IV inhibitors: a promising new therapeutic approach for the management of type 2 diabetes

CF Deacon, JJ Holst - The International Journal of Biochemistry & Cell …, 2006 - Elsevier
Glucagon-like peptide-1 is an insulinotropic hormone with antidiabetic potential due to its
spectrum of effects, which include glucose-dependent stimulation of insulin and inhibition of …

Emerging therapies mimicking the effects of amylin and glucagon-like peptide 1

MC Riddle, DJ Drucker - Diabetes care, 2006 - Am Diabetes Assoc
Current therapies for type 2 diabetes are frequently associated with inadequate control of
postprandial hyperglycemia, weight gain, and, in the case of oral agents, loss of efficacy …