Gamma-glutamyl hydrolase (GGH) is a lysosomal enzyme involved in the metabolism of
folates and anti-folates. It acts as an endo-and/or exo-peptidase to cleave gamma …

Membrane‐bound glutamate carboxypeptidase II (GCPII) is a zinc metalloenzyme that
catalyzes the hydrolysis of the neurotransmitter N‐acetyl‐l‐aspartyl‐l‐glutamate (NAAG) to …

The transmembrane peptidase prostate-specific membrane antigen (PSMA) is universally
upregulated in the vasculature of solid tumors, but its functional role in tumor angiogenesis …

Prostate-specific membrane antigen (PSMA) is highly expressed by both normal and
malignant prostate epithelial cells and by the neovasculature of many tumor types; however …

Prostate-specific membrane antigen (PSMA) provides an attractive target for the
development of targeted chemotherapeutics for prostate cancer. We have designed and …

Prostate cancer represents an ideal target for radioimmunotherapy based on the pattern of
spread, including bone marrow and lymph nodes, sites that typically receive high levels of …

BACKGROUND Intraprostatic PSMA targeted prodrugs/protoxins are under development in
our laboratory. Future toxicologic studies of these therapies require identification of animal …

Prostate-specific membrane antigen (PSMA) is a type II membrane protein that has attracted
significant attention as a target for immunioscintigraphic and radioimmunotherapeutic …

The prostate-specific membrane antigen (PSMA), a product of the folate hydrolase (FOLH1)
gene, is highly expressed as a largely extracellular membrane-anchored protein in …

Prostate-specific membrane antigen (PSMA) is a transmembrane protein with a highly
restricted profile of expression. Expression is primarily limited to secretory cells of the …