PSA-NCAM in mammalian structural plasticity and neurogenesis

L Bonfanti - Progress in neurobiology, 2006 - Elsevier
Polysialic acid (PSA) is a linear homopolymer of α2-8-N acetylneuraminic acid whose major
carrier in vertebrates is the neural cell adhesion molecule (NCAM). PSA serves as a potent …

Polysialylated neural cell adhesion molecule is involved in induction of long-term potentiation and memory acquisition and consolidation in a fear-conditioning …

O Senkov, M Sun, B Weinhold… - Journal of …, 2006 - Soc Neuroscience
Polysialic acid (PSA) regulates functions of the neural cell adhesion molecule (NCAM)
during development and in neuroplasticity in the adult; the underlying mechanisms at …

Association between polymorphisms in the promoter region of the sialyltransferase 8B (SIAT8B) gene and schizophrenia

M Arai, K Yamada, T Toyota, N Obata, S Haga… - Biological …, 2006 - Elsevier
BACKGROUND: Sialyltransferase 8B (SIAT8B) and 8D (SIAT8D) are two
polysialyltransferases that catalyze the transfer of polysialic acid (PSA) to the neural cell …

Neural cell adhesion molecule-associated polysialic acid inhibits NR2B-containing N-methyl-D-aspartate receptors and prevents glutamate-induced cell death

MSL Hammond, C Sims, K Parameshwaran… - Journal of Biological …, 2006 - ASBMB
The neural cell adhesion molecule (NCAM) and its associated glycan polysialic acid play
important roles in the development of thenervoussystemandN-methyl-d-aspartate (NMDA) …

Nitric oxide and synaptic dynamics in the adult brain: physiopathological aspects

B Moreno-López, D Gonzáylez-Forero - Reviews in the …, 2006 - degruyter.com
The adult brain retains the capacity to rewire mature neural circuits in response to
environmental changes, brain damage or sensory and motor experiences. Two plastic …

Hippocampal up‐regulation of NCAM expression and polysialylation plays a key role on spatial memory

C Venero, AI Herrero, K Touyarot… - European Journal of …, 2006 - Wiley Online Library
Memory formation has been associated with structural and functional modifications of
synapses. Cell adhesion molecules are prominent modulators of synaptic plasticity. Here …

Elevated levels of neural recognition molecule L1 in the cerebrospinal fluid of patients with Alzheimer disease and other dementia syndromes

H Strekalova, C Buhmann, R Kleene, C Eggers… - Neurobiology of …, 2006 - Elsevier
In this study we surveyed a total of 218 cerebrospinal fluid (CSF) samples from patients with
different neurological diseases including Alzheimer disease, non-Alzheimer forms of …

In vivo synaptic plasticity in the dentate gyrus of mice deficient in the neural cell adhesion molecule NCAM or its polysialic acid

L Stoenica, O Senkov… - European Journal of …, 2006 - Wiley Online Library
The neural cell adhesion molecule NCAM and its associated polysialic acid (PSA) play
important roles in synaptic plasticity in the CA1 and/or CA3 regions of the hippocampus in …

Polysialic acid profiles of mice expressing variant allelic combinations of the polysialyltransferases ST8SiaII and ST8SiaIV

SP Galuska, I Oltmann-Norden, H Geyer… - Journal of Biological …, 2006 - ASBMB
The post-translational modification of the neural cell adhesion molecule (NCAM) by
polysialic acid (polySia) represents a remarkable example of dynamic modulation of homo …

Glycobiology of neural stem cells

RK Yu, M Yanagisawa - … Formerly Current Drug Targets-CNS & …, 2006 - ingentaconnect.com
The mammalian central nervous system is organized by a variety of cells, such as neurons
and glial cells, that are generated from a common progenitor, the neural stem cell (NSC) …