Family-based designs in the age of large-scale gene-association studies
Both population-based and family-based designs are commonly used in genetic association
studies to locate genes that underlie complex diseases. The simplest version of the family …
studies to locate genes that underlie complex diseases. The simplest version of the family …
Sequence and haplotype analysis supports HLA-C as the psoriasis susceptibility 1 gene
RP Nair, PE Stuart, I Nistor, R Hiremagalore… - The American Journal of …, 2006 - cell.com
Previous studies have narrowed the interval containing PSORS1, the psoriasis-susceptibility
locus in the major histocompatibility complex (MHC), to an∼ 300-kb region containing HLA …
locus in the major histocompatibility complex (MHC), to an∼ 300-kb region containing HLA …
A common genetic variant is associated with adult and childhood obesity
A Herbert, NP Gerry, MB McQueen, IM Heid, A Pfeufer… - Science, 2006 - science.org
Obesity is a heritable trait and a risk factor for many common diseases such as type 2
diabetes, heart disease, and hypertension. We used a dense whole-genome scan of DNA …
diabetes, heart disease, and hypertension. We used a dense whole-genome scan of DNA …
Glutamate transporter gene SLC1A1 associated with obsessive-compulsive disorder
PD Arnold, T Sicard, E Burroughs… - Archives of general …, 2006 - jamanetwork.com
Context There is strong evidence from family and twin studies that genetic determinants play
an important role in the etiology of obsessive-compulsive disorder (OCD). In the only …
an important role in the etiology of obsessive-compulsive disorder (OCD). In the only …
Evaluation of a susceptibility gene for schizophrenia: genotype based meta-analysis of RGS4 polymorphisms from thirteen independent samples
ME Talkowski, H Seltman, AS Bassett… - Biological …, 2006 - Elsevier
BACKGROUND: Associations between schizophrenia (SCZ) and polymorphisms at the
regulator of G-protein signaling 4 (RGS4) gene have been reported (single nucleotide …
regulator of G-protein signaling 4 (RGS4) gene have been reported (single nucleotide …
Association testing of the positional and functional candidate gene SLC1A1/EAAC1 in early-onset obsessive-compulsive disorder
DE Dickel, J Veenstra-VanderWeele… - Archives of general …, 2006 - jamanetwork.com
Context The first 2 independent linkage studies for obsessive-compulsive disorder (OCD)
identified a region on 9p24 with suggestive evidence for linkage. The glutamate transporter …
identified a region on 9p24 with suggestive evidence for linkage. The glutamate transporter …
Association between the arginine vasopressin 1a receptor (AVPR1a) gene and autism in a family-based study: mediation by socialization skills
N Yirmiya, C Rosenberg, S Levi, S Salomon… - Molecular …, 2006 - nature.com
We examined three microsatellites in the arginine vasopressin 1a receptor gene (AVPR1a),
two in the promoter region (RS1 and RS3) and an intronic microsatellite (AVR), for …
two in the promoter region (RS1 and RS3) and an intronic microsatellite (AVR), for …
N-methyl-D-aspartate receptor NR2B subunit gene GRIN2B in schizophrenia and bipolar disorder: Polymorphisms and mRNA levels
The NR2B protein is a critical structural and functional subunit of the NMDA glutamate
receptor. The glutamate neurotransmitter system has been implicated in psychosis and …
receptor. The glutamate neurotransmitter system has been implicated in psychosis and …
Variation in genes involved in the RANKL/RANK/OPG bone remodeling pathway are associated with bone mineral density at different skeletal sites in men
In order to assess the contribution of polymorphisms in the RANKL (TNFSF11), RANK
(TNFRSF11A) and OPG (TNFRSF11B) genes to variations in bone mineral density (BMD), a …
(TNFRSF11A) and OPG (TNFRSF11B) genes to variations in bone mineral density (BMD), a …
Paraoxonase cluster polymorphisms are associated with sporadic ALS
M Saeed, N Siddique, WY Hung, E Usacheva, E Liu… - Neurology, 2006 - AAN Enterprises
Background: Paraoxonases (PONs) are involved in the detoxification of organophosphate
pesticides and chemical nerve agents. Due to a reported possible twofold increased risk of …
pesticides and chemical nerve agents. Due to a reported possible twofold increased risk of …