Antiresorptive agents help to restore skeletal balance by reducing bone turnover, primarily at
the tissue level. Another therapeutic approach is to enhance bone formation with the use of …

Background: Bisphosphonates suppress osteoclast activity, and their intravenous use has
been reported in hundreds of cases to be associated with osteonecrosis in the jaw. Little is …

FE modeling was used to estimate the biomechanical effects of teriparatide and alendronate
on lumbar vertebrae. Both treatments enhanced predicted vertebral strength by increasing …

Scaffolds, also called bioscaffolds, are needed in all tissue engineering applications as
carriers for cells and biochemical factors, as constructs providing appropriate mechanical …

Using bone histomorphometry, we found that a 1‐month treatment with PTH (1–34)[hPTH (1–
34)] stimulated new bone formation on cancellous, endocortical, and periosteal bone …

Intermittent administration of parathyroid hormone peptides has anabolic skeletal effects and
reduces fracture risk in postmenopausal women with osteoporosis but the cellular and …

Vertebral fractures due to osteoporosis commonly occur under non-traumatic loading
conditions. This problem affects more than 1 in 3 women and 1 in 10 men over a lifetime …

We showed that the IGF‐IR–null mutation in mature osteoblasts leads to less bone and
decreased periosteal bone formation and impaired the stimulatory effects of PTH on …

By conventional 2-dimensional, histomorphometric analysis, we and others have previously
shown that cancellous bone architecture is preserved in mild primary hyperparathyroidism …

Bone grafting is commonly used to treat skeletal disorders associated with large bone defect
or unstable joint. It can take several months, however, to achieve a solid union and bony …