Background Male hormonal contraception has been an elusive goal. Administration of sex
steroids to men can shut off sperm production through effects on the pituitary and …

The epididymis is critically dependent on the presence of the testis. Although several
hormones, such as retinoids and progestins, and factors secreted directly into the …

BACKGROUND Results from mice lacking the androgen receptor (AR) showed that it is
critical for the proper development and function of the testes. The aim of this study was to …

Male hormonal contraceptive regimens function by suppressing gonadotropin secretion,
resulting in a dramatic decrease in testicular androgen biosynthesis and spermatogenesis …

Control of testicular steroidogenesis and gametogenesis represents the main target of
hormonal male contraception. The suppression of testosterone as a Leydig cell product and …

Hormones play a crucial role in endocrine-mediated tumorigenesis and have been shown to
influence cancer cell growth and progression. However, androgens and estrogens exert …