At first glance, cancer and ageing would seem to be unlikely bedfellows. Yet the origins for
this improbable union can actually be traced back to a sequence of tragic—and some say …

Cell division in mammalian cells is driven by protein kinases that regulate progression
through the various phases of the cell cycle. Cyclin-dependent kinases (Cdks) regulate cell …

An abnormal chromosome number, aneuploidy, is a common characteristic of tumor cells.
Boveri proposed nearly 100 years ago that aneuploidy causes tumorigenesis, but this has …

We present GENECODIS, a web-based tool that integrates different sources of information to
search for annotations that frequently co-occur in a set of genes and rank them by statistical …

Mad2 is an essential component of the spindle checkpoint that blocks activation of Separase
and dissolution of sister chromatids until microtubule attachment to kinetochores is …

Mutations in the gene encoding nuclear lamin A (LA) cause the premature aging disease
Hutchinson–Gilford Progeria Syndrome. The most common of these mutations results in the …

Tumor cell proliferation is frequently associated with genetic or epigenetic alterations in key
regulators of the cell cycle. Most known oncogenes and tumor suppressors target entry into …

The physiological role of the mitotic checkpoint protein Bub1 is unknown. To study this role,
we generated a series of mutant mice with a gradient of reduced Bub1 expression using wild …

Aneuploidy, an aberrant chromosome number, has been recognized as a common
characteristic of cancer cells for more than 100 years and has been suggested as a cause of …

Mitotic arrest–deficient protein 1 (MAD1) is a component of the mitotic spindle assembly
checkpoint. We have created a knockout mouse model to examine the physiologic …