Psoriasis is a chronic, inflammatory and hyperproliferative skin disease with a genetic basis.
While epidermal hyperplasia and altered keratinocyte differentiation are prominent features …

Nearly forty years ago, Susumu Ohno proposed that one or two rounds of whole genome
duplication took place close to the origin of vertebrates. The refined version of this proposal …

The HLA region encodes several molecules that play key roles in the immune system.
Strong association between the HLA region and autoimmune disease (AID) has been …

A recent high-density linkage screen confirmed that the HLA complex contains the strongest
genetic factor for the risk of multiple sclerosis (MS). In parallel, a linkage disequilibrium …

Objective Variation in the major histocompatibility complex (MHC) on chromosome 6p21 is
known to influence susceptibility to multiple sclerosis with the strongest effect originating …

The association of the major histocompatibility complex (MHC) with SLE is well established
yet the causal variants arising from this region remain to be identified, largely due to …

Background Current criteria for the selection of unrelated donors for hematopoietic cell
transplantation (HCT) include matching for the alleles of each human leukocyte antigen …

The strong genetic association suggests a direct involvement of HLA in the pathogenesis of
drug hypersensitivity when the HLA molecule presents an antigenic drug for T cell activation …

The three-dimensional (3D) organization of the chromosomal fiber in the human interphase
nucleus is an important but poorly understood aspect of gene regulation. Here we …

Crohn's disease (CD) and ulcerative colitis (UC), also known as inflammatory bowel
diseases (IBD), are characterized by chronic inflammation of the gastrointestinal tract. IBD is …