Nicotinamide adenine dinucleotide (NAD+) is both a coenzyme for hydride-transfer enzymes
and a substrate for NAD+-consuming enzymes, which include ADP-ribose transferases, poly …

Abstract Sirtuins (SIRTs 1− 7), or class III histone deacetylases (HDACs), are protein
deacetylases/ADP ribosyltransferases that target a wide range of cellular proteins in the …

The NAD+-dependent deacetylase Sir2 regulates life span in lower eukaryotes. The
mammalian ortholog SIRT1 regulates physiological processes including apoptosis, fat …

Although NAD+ biosynthesis is required for Sir2 functions and replicative lifespan in yeast,
alterations in NAD+ precursors have been reported to accelerate aging but not to extend …

In contrast to stably repressive, constitutive heterochromatin and stably active, euchromatin,
facultative heterochromatin has the capacity to alternate between repressive and activated …

The sirtuin family of histone deacetylases (HDACs) was named after their homology to the
Saccharomyces cerevisiae gene silent information regulator 2 (Sir2). In the yeast, Sir2 has …

Calorie restriction (CR) robustly extends the lifespan of numerous species. In the yeast
Saccharomyces cerevisiae, CR has been proposed to extend lifespan by boosting the …

Extending the productive lifespan of human cells could have major implications for diseases
of aging, such as atherosclerosis. We identified a relationship between aging of human …

Sirtuins are NAD+-dependent protein deacetylases and are emerging as molecular targets
for the development of pharmaceuticals to treat human metabolic and neurological diseases …

The risk of having cancer increases with age probably because progenitor cells from mature
organisms accumulate enough molecular lesions to evade the homeostatic control of their …