Historically, the neuron has been the conceptual focus for almost all of neuroscience
research. In recent years, however, the concept of the neurovascular unit has emerged as a …

The blood brain barrier (BBB) evolved to preserve the microenvironment of the highly
excitable neuronal cells to allow for action potential generation and propagation. Intricate …

Thinning and discontinuities within the vascular basement membrane (VBM) are associated
with leakage of the plasma protein prothrombin across the blood–brain barrier (BBB) in …

Abnormalities in the cerebral microvasculature are common in Alzheimer disease (AD).
Expression levels of the water channels aquaporin 1 and aquaporin 4 (AQP1, AQP4) were …

Agrin is a heparan sulfate proteoglycan of the extracellular matrix and is known for
organizing the postsynaptic differentiation of the neuromuscular junction. Increasing …

Clinical neuroscientists have focused increasing attention on white matter connections in the
brain and on the effects of aging and disease on these connections. Recent advances in …

Amyloid precursor protein (APP) encodes a transmembrane protein that is well established
as contributing a crucial role to the etiology of Alzheimer's disease. We have generated …

Extracellular matrix (ECM) molecules and growth factors, such as fibroblast growth factor
(FGF), play a crucial role in Alzheimer's disease (AD). The purpose of this investigation was …

The blood–brain barrier (BBB) is a specialized tissue interface that provides an important
homeostatic and immunosurveillance role in the CNS. Unlike most microvascular tissues …

Muchos de los factores y cofactores de la coagulación son constitutivos del Sistema
Nervioso. Hasta la fecha, gran parte de los estudios recientes se han centrado en la …