Alzheimer disease and cerebrovascular dementia are two common causes of dementia and,
by present diagnostic criteria, are mutually exclusive using vascular pathology as an …

The pathologic lesions of Alzheimer's disease (AD) are characterized by accumulation of
protein aggregates consisting of intracellular or extracellular misfolded proteins. The …

Thinning and discontinuities within the vascular basement membrane (VBM) are associated
with leakage of the plasma protein prothrombin across the blood–brain barrier (BBB) in …

The extracellular matrix (ECM) is a substrate upon which cells migrate, proliferate and
differentiate. It is involved in the maintenance of cytoarchitecture, regulation of homeostasis …

Heparan sulfate proteoglycans mediate cell adhesion and control the activities of numerous
growth and motility factors. They play a critical role in carcinogenesis and tumor progression …

Agrin is a key heparan sulfate proteoglycan involved in the development and maintenance
of synaptic junctions between nerves and muscles. Agrin's important functions include …

WO2007006858A2 - Method for treatment of cardiovascular and metabolic diseases and
detecting the risk of the same - Google Patents WO2007006858A2 - Method for treatment of …

Parkinson's disease (PD) is a multifactorial movement disorder in which both genetic and
especially environmental factors play important roles. Substantial evidence implicates the …