Great strides have been made in our understanding of the pathophysiology of primary
aldosteronism syndrome since Conn's description of the clinical presentation of a patient …

Plasma renin levels can be used to classify hypertension. A significant proportion of
hypertensive individuals display a low‐renin profile and thus low‐renin hypertension (LRH) …

Objective: Obstructive sleep apnea (OSA) and primary aldosteronism are common in
subjects with resistant hypertension; it is unknown, however, if the two disorders are causally …

The source of aldosterone in 30–40% of patients with primary hyperaldosteronism (PA) is
unilateral aldosterone-producing adenoma (APA). The mechanisms causing elevated …

Background: The renal damage that is present in primary aldosteronism might reflect
functional and potentially reversible abnormalities that are initiated by glomerular …

Aldosterone-producing adenomas (APAs) are a common cause of arterial hypertension, but
the underlying molecular mechanisms are unknown, although a transcriptional modulation …

Aldosterone and angiotensin II (ANG II) contribute to the development and progression of
renal damage. Here we investigated the effects of bone morphogenetic proteins (BMPs) on …

Context: In primary aldosteronism, elevated serum 18-hydroxycorticosterone (18OHB)
suggests aldosterone-producing adenoma (APA) rather than bilateral, idiopathic …

Regulators of G-protein signaling (RGS proteins) interact with Ga subunits of heterotrimeric
G-proteins, accelerating the rate of GTP hydrolysis and finalizing the intracellular signaling …

The mineralocorticoid aldosterone, mainly produced by the adrenal gland, is essential for
life, but an abnormally excessive secretion causes severe pathological effects including …